Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78882 |
NF-κB-IN-12
|
NF-κB | NF-κB |
NF-κB-IN-12 (compound 3h),作为一种NF-κB抑制剂,在急性肺损伤研究中具有应用潜力,其IC50值为1.02 μM。 | |||
T79999 |
NF-κB-IN-13
|
NF-κB | NF-κB |
NF-κB-IN-13(compound 12)在RAW264.7巨噬细胞中显著抑制了LPS诱导的NF-κB激活以及NO生成,表现出其抗炎效果。 | |||
T36713 |
Streptochlorin
|
||
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the productio... | |||
T23028 |
MRT67307 HCl (1190378-57-4 free base)
MRT67307 HCl |
Others | Others |
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth... |