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Cat. No.	Product Name	Target	Signaling Pathways
T35922	NAADP (sodium salt)
	Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs). NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to...
T83801	ε-NAADP+ sodium Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate
	ε-NAADP+是钙动员诱导剂NAADP的荧光衍生物。在海胆卵细胞匀浆中诱导钙释放(EC50 = 5 µM)。ε-NAADP+在275 nm和410 nm分别显示激发/发射峰值，且在DMSO中的相对发射增加了三倍。
T23049	NAADP tetrasodium salt	Others	Others
	Ca2+ mobilizing agent
T12205	Ned 19	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
T22670	cis-Ned 19	Others	Others
	nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist
T12205L	trans-Ned 19	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	trans-Ned 19 is a NAADP antagonist and TPC blocker and inhibits the calcium signal in human umbilical vein endothelial cells and the rat aorta relaxation in response to low histamine concentrations.
T63649	Ned-K
	Ned-K 是一种烟酸腺嘌呤二核苷酸磷酸 (NAADP) 拮抗剂，对心肌缺血和再灌注 (sIR) 诱导的钙振荡表现出抑制作用。
T36805	TPC2-A1-N TPC2-A1-N
	TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through independent binding sites. TPC2-A1-N has inverse effects on key lysosomal activities and increases the pH in the lysosomal lumen in a TPC2-dependent manner[1].

化合物

NAADP (sodium salt)

Cat.No: T35922

ε-NAADP+ sodium

Cat.No: T83801

Synonym: Etheno-NAADP,β-Nicotinic Acid-1,N6-Ethenoadenine dinucleotide phosphate,Nicotinic Acid adenine dinucleotide phosphate

NAADP tetrasodium salt

Cat.No: T23049

Target: Others

Cat.No: T12205

Target: Calcium Channel

Cat.No: T22670

Target: Others

Cat.No: T12205L

Target: Calcium Channel

Cat.No: T63649

Cat.No: T36805

Synonym: TPC2-A1-N

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