Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12102 |
Mps1-IN-1
|
Others | Others |
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM ) | |||
T16130 |
Mps1-IN-3
|
Kinesin | Cytoskeletal Signaling |
Mps1-IN-3 是一种有效的选择性 MPS1 激酶抑制剂,IC50值为 50 nM。 | |||
T1839 |
Mps1-IN-2
|
Kinesin; PLK | Cell Cycle/Checkpoint; Cytoskeletal Signaling |
Mps1-IN-2 是一种 ATP 竞争性Mps1/Plk1选择性双重抑制剂,对 Mps1 的IC50和Kd 值分别为 145 和 12 nM,对 Plk1 的Kd 值为 61 nM。 | |||
T70095 |
Mps1-IN-1 dihydrochloride
|
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Mps1-IN-1 dihydrochloride 是一种有效的,ATP 竞争性 Mps1激酶抑制剂,IC50为 367 nM。Mps1-IN-1 dihydrochloride 抑制 Mps1有丝分裂激酶活性并沉默纺锤体组装检查点 (SAC) 功能。Mps1-IN-1 dihydrochloride 降低癌细胞和“正常”细胞的活力。 | |||
T37050 |
MPS1/TTK Inhibitor
MPS1/TTK Inhibitor |
||
MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells entering anaphase within 15 minutes, indicating MPS1 checkpoint inhibition, when used at a concentration of 100 nM. MPS1/TTK inhibitor (50 and 100 nM) increases the number of missegr... | |||
T73229 |
Mps1-IN-4
|
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Mps1-IN-4,一种针对Monopolar spindle 1 (Mps1)的选择性抑制剂,展现出抗增殖特性,适用于癌症领域的研究。 | |||
T78965 |
Mps1-IN-6
|
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Mps1-IN-6是一种有效的Mps1抑制剂,具有2.596 nM的IC50值,显示出抗增殖和抗癌活性。 | |||
T73308 |
Mps1-IN-5
|
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Mps1-IN-5是一种口服活性的Mps1抑制剂,其IC50为29 nM。它可诱导Apoptosis和G2/M期的胞周期停滞,展现出抗增殖和抗肿瘤活性,并通过抑制Mps1磷酸化来诱导DNA损伤。 | |||
T73483 |
RMS-07
|
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RMS-07 是 Monopolar Spindle Kinase 1 (MPS1/TTK)的共价抑制剂,其 IC50值为 13.1 nM。RMS-07靶向激酶结构域的半胱氨酸。 | |||
T71082 |
DW532
|
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DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 values were 4.9 and 5.5 μmol/L, respectively), and suppressed their downstream signaling. DW532 dose-dependently inhibited tubulin polymerization via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. In a panel of human ca... |