Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79036 | Mcl-1 inhibitor 13 | ||
Mcl-1 inhibitor13 (Example 9),一种MCL-1抑制剂(Ki: 8.2 nM),主要用于癌症相关研究。 | |||
T70779 |
BPR1J-340
|
||
BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD(+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibit... |