Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11967 |
Mcl-1 antagonist 1
|
Others | Others |
Mcl-1 antagonist 1 is a Mcl-1 protein antagonist. | |||
T14665L |
Motixafortide TFA(664334-36-5,Free)
TF 14016 TFA,BKT140 TFA,BL-8040 TFA,T140 TFA |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) 是 CXCR4 的拮抗剂,IC50 为 ~1 nM。它通过改变 miR-15a/16-1 表达下调 ERK、BCL-2、MCL-1 和 cyclin-D1 来诱导 AML 原始细胞凋亡。 | |||
T13459 |
(+)-Apogossypol
Apogossypol,NSC736630 |
Others | Others |
(+)-Apogossypol is an antagonist of pan-BCL-2. (+)-Apogossypol binds to Mcl-1(Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively). | |||
T29060 |
UNBS-1450
UNBS 1450,UBS1450,UBS-1450,UBS 1450 |
||
UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomolar concentrations, UNBS-1450 induce |