Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11934 |
Macitentan-d4
Macitentan D4,ACT-064992 D4 |
Endothelin Receptor | GPCR/G Protein |
Macitentan-d4 (ACT-064992 D4) 是一种 Macitentan 氘代物,可被当作非多肽 ETA 和 ETB (内皮素受体)双拮抗剂。Macitentan-d4 比 Macitentan 毒性更低,半衰期更长,可用于研究由内皮素受体介导介导的疾病。 | |||
T10351 |
Aprocitentan D4
ACT-132577 D4 |
Others | Others |
Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5). |