Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37050 |
MPS1/TTK Inhibitor
MPS1/TTK Inhibitor |
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MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells entering anaphase within 15 minutes, indicating MPS1 checkpoint inhibition, when used at a concentration of 100 nM. MPS1/TTK inhibitor (50 and 100 nM) increases the number of missegr... | |||
T22289 |
CFI-402257
|
Kinesin | Cytoskeletal Signaling |
CFI-402257 是 Mps1/TTK 激酶的选择性抑制剂(Mps1 Ki = 0.09 nM;EC50 = 6.5 nM),可用于肝细胞癌疾病的研究。 | |||
T73483 |
RMS-07
|
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RMS-07 是 Monopolar Spindle Kinase 1 (MPS1/TTK)的共价抑制剂,其 IC50值为 13.1 nM。RMS-07靶向激酶结构域的半胱氨酸。 |