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Cat. No. Product Name Target Signaling Pathways
T37050 MPS1/TTK Inhibitor

MPS1/TTK Inhibitor

MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells entering anaphase within 15 minutes, indicating MPS1 checkpoint inhibition, when used at a concentration of 100 nM. MPS1/TTK inhibitor (50 and 100 nM) increases the number of missegr...

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MPS1/TTK Inhibitor
Cat.No: T37050
Synonym: MPS1/TTK Inhibitor
Target:
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