Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12076L |
ML218
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ML218 是一种具有口服活性、选择性、高效性且可穿透血脑屏障的 T 型 Ca2+ 通道抑制剂(Cav3.2 和 Cav3.3 的 IC50 分别为 310 nM 和 270 nM)。ML218 可抑制丘脑下核(STN)神经元的突发性活动。 | |||
T12076 |
ML218 hydrochloride
|
Others | Others |
ML218 hydrochloride is a selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor (Cav3.2 and Cav3.3 with IC50s of 310 nM and 270 nM , respectively). | |||
T38072 | HSGN-218 | ||
HSGN-218 is a gut-restrictive antibiotic.1It is active againstC. difficile(MIC = 0.007 μg/ml) and clinical isolates ofC. difficile(MICs = 0.003-0.03 μg/ml) and is not cytotoxic to Caco-2 cells when used at concentrations ranging from 4 to 64 μg/ml. HSGN-218 (50 mg/kg) increases survival and protects mice fromC. difficilerecurrence in mouse models ofC. difficileinfection. 1.Naclerio, G.A., Abutaleb, N.S., Li, D., et al.Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses rec... | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
||
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... |