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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T8497 SX-682

CXCR Autophagy; GPCR/G Protein; Immunology/Inflammation
SX-682 是口服有效的 CXCR1和 CXCR2变构抑制剂,可以阻断肿瘤髓系抑制细胞募集并增强 T 细胞活化和抗肿瘤免疫,具有治疗去势抵抗性前列腺癌的潜力。
T61356 CXCR2 antagonist 3

CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar potencies against CXCR2. Moreover, CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs, while enhancing the infiltration of CD3+ T lymphocytes into Pan02 tumor tissues [1].
T70928 CB-1158-analog

CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cell...

化合物

SX-682
Cat.No: T8497
Synonym:
Target: CXCR
CXCR2 antagonist 3
Cat.No: T61356
Synonym:
Target:
CB-1158-analog
Cat.No: T70928
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T2788 Baccatin III

巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ

Others Others
Baccatin III (Baccatin Ⅲ) 是一种分离自太平洋紫杉树和其近缘种中的天然产物,能够减少 MDSCs 积累并抑制其功能,延缓肿瘤发展进程。

天然产物

Baccatin III
Cat.No: T2788
Synonym: 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ
Target: Others
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