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Cat. No. Product Name Target Signaling Pathways
T64529 MDL-800

MDL 800,MDL800

Sirtuin Chromatin/Epigenetic; DNA Damage/DNA Repair
SIRT6, responsible for deacetylation of histone H3 Nε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac), is a tumor suppressor which has frequently been found to have low expression in various cancers. MDL-800 is a selective SIRT6 activator. It increased the deacetylase activity of SIRT6 by up to 22-fold and led to a global decrease in H3K9ac and H3K56ac levels in human hepatocellular carcinoma (HCC) cells. Also, it inhibited the proliferation of HCC cells via SIRT6-driven cell-cycle arrest and was eff...

化合物

MDL-800
Cat.No: T64529
Synonym: MDL 800,MDL800
Target: Sirtuin
TargetMol Loading
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