Cat. No. | Product Name | Target | Signaling Pathways |
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T35799 |
MBX-8025 (sodium salt)
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MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin... | |||
T12876 |
Seladelpar sodium salt
RWJ-800025 sodium salt,MBX-8025 sodium salt |
Others | Others |
Seladelpar sodium salt (MBX-8025) 是一种具有口服活性、有效且特异性的PPARδ激动剂,EC50值为 2 nM。它对 PPARδ 的选择性分别是对 PPARα 和 PPARγ 的 750 和 2500 多倍。 |