Cat. No. | Product Name | Target | Signaling Pathways |
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T81881 | MAGL-IN-10 | MAGL | Metabolism |
MAGL-IN-10为一种可逆MAGL抑制剂,展现出优良的ADME特性且体内毒性低。该化合物适用于癌症、神经系统疾病和炎症病理学研究。 | |||
T62671 | FAAH/MAGL-IN-3 | ||
FAAH/MAGL-IN-3 (Compound 10) 是一种不可逆的脂肪酸酰胺水解酶 (FAAH)和单酰基甘油脂酶 (MAGL)双重抑制剂,能够作用于 FAAH (IC50: 179 nM) 和 MAGL (IC50: 759 nM)。FAAH/MAGL-IN-3 表现出很小的 PAMPA (平行人工膜渗透性试验) 透过性。 | |||
T28235 |
OMDM169
OMDM 169,OMDM-169 |
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OMDM169 is a potent and selective MAGL inhibitor. OMDM169 could enhances 2-AG levels and of exerts analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM<IC(50)<0.41 microM towards 2-AG hydrolysing activities in | |||
T36498 |
CAY10762
CAY10762 |
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CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain. 1.Castelli, R., Scalvini, L., Vacondio, F., et al.Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteinesJ. Med. Chem.63(... |