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Cat. No.	Product Name	Target	Signaling Pathways
T36626	Lys-CoA
	Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo. Lau et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 5 589 PMID:10882143 \|Liu et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451 846 PMID:18273021 \|Burns et al (...
T73951	Lys-CoA TFA
	Lys-CoA TFA为选择性p300组蛋白乙酰转移酶(HAT)抑制剂，IC50值介于50-500 nM。其对p300的选择性超过PCAF 100倍，PCAF的IC50值为200 μM。此外，Lys-CoA TFA能够抑制依赖p300-HAT活性的转录激活。