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Targets Recommended: Gamma-secretase

3

抑制剂 & 化合物

12

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T9015 LY900009

Gamma-secretase Neuroscience; Proteases/Proteasome; Stem Cells
LY900009 是一种通过选择性抑制 γ-分泌酶蛋白来抑制 Notch 信号传导的小分子抑制剂。
T15822 Ly93

Others Others
Ly93 是一种具有选择性和口服活性的鞘磷脂合成酶 2(SMS2)抑制剂(IC50:91 nM),可用于研究动脉粥样硬化。
T76633 (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin

(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin 为一种有效的加压素 V1 受体 (VP V1R) 拮抗剂,能显着降低大鼠的平均动脉压 (MAP)。

化合物

LY900009
Cat.No: T9015
Synonym:
Target: Gamma-secretase
Ly93
Cat.No: T15822
Synonym:
Target: Others
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin
Cat.No: T76633
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPK-00357 CD229 Protein, Human, Recombinant (His & Avi)

LY9,T100,AI893573,SLAMF3,Lgp100,C...

Human HEK293 Cells
CD229 was strongly and homogeneously overexpressed on the PC of patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, MM, and PC leukemia. CD229 was particularly overexpressed on those PC showing an abnormal phenotype such as expression of CD56. Most importantly, CD229 was also highly expressed on those cells in the patients' BM displaying the phenotype of chemotherapy-resistant and myeloma-propagating cells. CD229 Protein, Human, Recombinant (His & Avi) is...
TMPK-00358 CD229 Protein, Human, Recombinant (His & Avi), Biotinylated

T100,Lgp100,LY9,AI893573,CD22...

Human HEK293 Cells
CD229 was strongly and homogeneously overexpressed on the PC of patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, MM, and PC leukemia. CD229 was particularly overexpressed on those PC showing an abnormal phenotype such as expression of CD56. Most importantly, CD229 was also highly expressed on those cells in the patients' BM displaying the phenotype of chemotherapy-resistant and myeloma-propagating cells. CD229 Protein, Human, Recombinant (His & Avi), B...
TMPK-01258 SLAMF7 Protein, Cynomolgus, Recombinant (His)

19A,CD319,SLAMF7,Novel Ly9

Cynomolgus HEK293 Cells
SLAMF7 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.55 kDa and the accession number is XP_005541294.2.
TMPK-00225 SLAMF7 Protein, Human, Recombinant (His & Avi)

CRACC,Novel Ly9,CD319,19...

Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.3 kDa and the accession number is Q9NQ25-1.
TMPJ-01442 SLAMF7 Protein, Rhesus macaque, Recombinant (His)

CD2 Subset 1,CD2-Like Receptor-Activating Cytotoxic Cells,No...

Rhesus HEK293 Cells
SLAMF7 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 KDa and the accession number is F7HQ72.
TMPJ-00359 SLAMF3 Protein, Human, Recombinant (His)

Signaling lymphocytic activation molecule 3,CD22

Human HEK293 Cells
SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains. The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3. Within the first two Ig-like domains that are common to all SLAM proteins, human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, ...
TMPJ-00221 SLAMF7 Protein, Human, Recombinant (His & Avi), Biotinylated

Membrane Protein FOAP-12,Novel Ly9,CRACC,S...

Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 35-55 KDa and the accession number is Q9NQ25.
TMPJ-00222 SLAMF7 Protein, Human, Recombinant (mFc)

CD2 Subset 1,CRACC,CD319,CS1,Membrane Protein FOAP-...

Human HEK293 Cells
SLAMF7 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is Q9NQ25.
TMPJ-01154 SLAMF3 Protein, Mouse, Recombinant (His)

SLAM family member 3,T-lymphocyte surface ...

Mouse HEK293 Cells
CD229(SLAMF3) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature mouse CD229 consists of a 406 aa extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains, a 21 aa transmembrane segment, and a 180 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs ITSMs. Within the first two Ig-like domains that are common to all SLAM proteins, mouse CD229 shares 22%-36% aa sequence identity with mouse 2B4, BLAME, CD2F10,...
TMPY-03999 MD2/LY96 Protein, Mouse, Recombinant (hFc)

lymphocyte antigen 96,ESOP-1,MD2,MD-2

Mouse HEK293 Cells
LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances the TLR4-dependent activa...
TMPK-00632 MD2/LY96 Protein, Cynomolgus, Recombinant (His)

ESOP-1,LY96,Lymphocyte antigen

Cynomolgus E. coli
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 17.97 kDa and the accession number is B3Y6B0.
TMPK-01242 MD2/LY96 Protein, Human, Recombinant (His)

MD-2,Ly-96,ESOP-1,Lymphocyte anti...

Human E. coli
MD2, a 160-residue accessory glycoprotein, is responsible for the recognition and binding of Gram-negative bacterial membrane component, lipopolysaccharide (LPS).Internalization of pathogen inside the mononuclear phagocytes has also been attributed to MD2 which leads to the clearance of pathogens from the host. MD2/LY96 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.07 kDa and the accession number is Q9Y6Y9-1.

重组蛋白

CD229 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00357
Species: Human
Expression System: HEK293 Cells
CD229 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00358
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01258
Species: Cynomolgus
Expression System: HEK293 Cells
SLAMF7 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00225
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPJ-01442
Species: Rhesus
Expression System: HEK293 Cells
SLAMF3 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00359
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPJ-00221
Species: Human
Expression System: HEK293 Cells
SLAMF7 Protein, Human, Recombinant (mFc)
Cat.No: TMPJ-00222
Species: Human
Expression System: HEK293 Cells
SLAMF3 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01154
Species: Mouse
Expression System: HEK293 Cells
MD2/LY96 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-03999
Species: Mouse
Expression System: HEK293 Cells
MD2/LY96 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00632
Species: Cynomolgus
Expression System: E. coli
MD2/LY96 Protein, Human, Recombinant (His)
Cat.No: TMPK-01242
Species: Human
Expression System: E. coli
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