Cat. No. | Product Name | Target | Signaling Pathways |
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T38128 |
Leukotriene D4
Leukotriene D4 MaxSpec® Standard,LTD4 |
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Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of... | |||
T68130 |
Pobilukast
SKF 104353 Z2,SKF 104353 |
Leukotriene Receptor | GPCR/G Protein |
Pobilukast (SKF 104353) 是一种选择性半胱氨酰白三烯受体拮抗剂,可阻断磷脂酰肌醇代谢和白三烯D诱导的血栓素合成,可用于研究过度心肌再灌注损伤 (MI/R) 大鼠限制心肌损伤。 | |||
T36660 |
Olsalazine-13C6
Olsalazine-13C6 |
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Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ... |