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Cat. No. Product Name Target Signaling Pathways
T3689L Ruboxistaurin mesylate

LY-333531,LY333531,LY 333531,LY-333531 Mesylate

Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/
T69990 Ruboxistaurin mesylate monohydrate

Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
T3689 Ruboxistaurin hydrochloride

Ruboxistaurin,LY333531 HCl,LY 333531 hydrochloride,芦布妥林

PKC Chromatin/Epigenetic; Cytoskeletal Signaling
Ruboxistaurin hydrochloride (LY 333531 hydrochloride) 是蛋白激酶 C(PKC) 的同工酶选择性抑制剂,竞争性且可逆地抑制 PKCβI 和 PKCβII,IC50 值分别为 4.7 和 5.9 nM。
T63013 Ruboxistaurin

Ruboxistaurin (LY333531) 是一种选择性的、口服具有活力的 PKC beta 抑制剂,其 Ki 值为 2 nM。Ruboxistaurin 以 ATP 依赖性的方式竞争性抑制 PKC beta I (IC50: 4.7 nM)。Ruboxistaurin 能够作用于 PKC beta II (IC50: 5.9 nM)。

化合物

Ruboxistaurin mesylate
Cat.No: T3689L
Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate
Target:
Ruboxistaurin mesylate monohydrate
Cat.No: T69990
Synonym:
Target:
Ruboxistaurin hydrochloride
Cat.No: T3689
Synonym: Ruboxistaurin,LY333531 HCl,LY 333531 hydrochloride,芦布妥林
Target: PKC
Ruboxistaurin
Cat.No: T63013
Synonym:
Target:
TargetMol Loading
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