Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2080 |
LCL161
|
IAP | Apoptosis |
LCL161 是一种 SMAC 模拟物,可有效结合并抑制多种 IAP。它抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1的 IC50分别为 35 和 0.4 nM。 | |||
T16905 |
SNIPER(BRD)-1
|
Others | Others |
SNIPER(BRD)-1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+)-JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway and effectively degrades cIAP1, cIAP2, and XIAP with IC50 values of 6.8 nM, 17 nM, and 49nM, respectively[1]. |