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Cat. No. Product Name Target Signaling Pathways
T11779 KRas G12C inhibitor 4

Ras GPCR/G Protein; MAPK
KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
T11738 K-Ras G12C-IN-4

Ras GPCR/G Protein; MAPK
K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。
T79799 pan-KRAS-IN-4

Ras GPCR/G Protein; MAPK
Pan-KRAS-IN-4 (compound 5) 为一种高效KRAS抑制剂,其IC50值分别为0.37 nM (Kras G12C) 和0.19 nM (Kras G12V)。
T36642 RAS/RAS-RAF-IN-1

RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1]. RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and has an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1]. [1]. Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.

化合物

KRas G12C inhibitor 4
Cat.No: T11779
Synonym:
Target: Ras
K-Ras G12C-IN-4
Cat.No: T11738
Synonym:
Target: Ras
pan-KRAS-IN-4
Cat.No: T79799
Synonym:
Target: Ras
RAS/RAS-RAF-IN-1
Cat.No: T36642
Synonym:
Target:
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