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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T62405 KDM1/CDK1-IN-1

KDM1/CDK1-IN-1 (compound 4) 是一种有效的 KDM1 (IC50: 0.096 μM) 和 CDK1 (IC50: 0.078 μM) 抑制剂。KDM1/CDK1-IN-1 能够将 HOP-92 细胞的细胞周期阻滞在 G2/M 期,并诱导其凋亡 (apoptosis)。KDM1/CDK1-IN-1 对 CCRF-CEM 细胞 (IC50: 16.34 μM)、HOP-92 细胞 (IC50: 3.45 μM) 和 Hep-G2 细胞 (IC50: 7.79 μM) 具有较强的细胞毒性。

化合物

KDM1/CDK1-IN-1
Cat.No: T62405
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-03056 LSD1 Protein, Human, Recombinant (His & GST)

BHC110,LSD1,KDM1

Human Baculovirus Insect Cells
LSD1 belongs to the flavin monoamine oxidase family. It contains 1 SWIRM domain and is a component of an RCOR/GFI/LSD1/HDAC complex. LSD1 interacts directly with GFI1 and GFI1B. LSD1 specifically removes histone H3K4me2 to H3K4me1 or H3K4me0 through a FAD-dependent oxidative reaction. When forming a complex with an androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. Thus LSD1 is considered to act as a coactivator or a corepressor. It may play...

重组蛋白

LSD1 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-03056
Species: Human
Expression System: Baculovirus Insect Cells
TargetMol Loading
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