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抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T38789 BMS-984923

BMS-984923, a highly potent silent allosteric modulator (SAM) of mGluR5, demonstrates exceptional binding affinity (K i = 0.6 nM). Additionally, this compound possesses favorable oral bioavailability and blood-brain barrier (BBB) penetration. BMS-984923 effectively inhibits the interaction between PrPC and mGluR5, preventing pathological Aβo signaling, while leaving physiological glutamate signaling unaffected.
T74185 (S,S)-BMS-984923

(S,S)-BMS-984923，BMS-984923的(S,S)-对映体，相较于其它对映体展现了较低的活性。(S,S)-BMS-984923对mGluR5受体的EC50值超过1μM，标明其在这一受体上的活性较弱。BMS-984923本身为一种高效的mGluR5沉默变构调节剂。

化合物

BMS-984923
Cat.No: T38789
Synonym:
Target:
(S,S)-BMS-984923
Cat.No: T74185
Synonym:
Target:
Species：
Human (13)
Cynomolgus (1)
Mouse (1)
Expression System：
HEK293 Cells (14)
Baculovirus Insect Cells (1)
Tag：
C-His (4)
C-His-Avi (4)
C-Avi (2)
C-hFc (1)
His (1)
His, Avi (1)
His, GST (1)
His, hFc (1)
Cat. No. Product Name Species Expression System
TMPY-00972 FGFR2 Protein, Human, Recombinant (His & hFc)

K-SAM,TK14,BBDS,fibroblast growth...

 Human HEK293 Cells
FGFR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67.6 kDa and the accession number is P21802-1.
TMPY-00423 FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)

BFR-1,KGFR,TK25,JWS,ECT1,K-SA...

 Human HEK293 Cells
FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66.3 kDa and the accession number is P21802-17.
TMPK-00398 FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)

Fibroblast growth factor receptor 2,CD332,FGFR2 β (IIIb) Dom...

 Human HEK293 Cells
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
TMPK-00847 FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His)

FGFR2 β (IIIb),KGFR,BEK,CD332,K-<...

 Mouse HEK293 Cells
FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.3 kDa and the accession number is P21803-2.
TMPK-00397 FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

K-sam,CD332,KGFR,Keratin...

 Human HEK293 Cells
FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.2 kDa and the accession number is P21802-1.
TMPK-00475 FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His)

K-sam,KSAM,KGFR...

 Cynomolgus HEK293 Cells
FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.2 kDa and the accession number is A0A2K5TL84-1.
TMPK-00400 FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated

Fibroblast growth factor receptor 2,KGFR,FGFR-2,

Human HEK293 Cells
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.3 kDa and the accession number is P21802-3.
TMPK-00399 FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated

Keratinocyte growth factor receptor,K-...

 Human HEK293 Cells
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
TMPK-00401 FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated

ECT1,K-SAM,CD332,CEK3,FGFR2 α,CFD...

 Human HEK293 Cells
Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs.
TMPY-00351 FGFR2 Protein, Human, Recombinant (beta IIIc, His)

fibroblast growth factor receptor 2,TK14,FGFR2 Prot...

 Human HEK293 Cells
FGFR2 Protein, Human, Recombinant (beta IIIc, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.2 kDa and the accession number is P21802-21.
TMPY-04273 FGFR2 Protein, Human, Recombinant (aa 1-378, His)

TK25,ECT1,JWS,fibroblast growth factor receptor 2,C...

 Human HEK293 Cells
FGFR2 Protein, Human, Recombinant (aa 1-378, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41.1 kDa and the accession number is P21802-3.
TMPY-04390 FGFR2 Protein, Human, Recombinant (aa 400-821, His & GST)

CFD1,ECT1,K-SAM,BEK,KGFR...

 Human Baculovirus Insect Cells
FGFR2 Protein, Human, Recombinant (aa 400-821, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.7 kDa and the accession number is P21802-1.
TMPY-06321 FGFR2 Protein, Human, Recombinant (alpha(IIIb), His & Avi), Biotinylated

ECT1,CEK3,JWS,TK14,K-SAM...

 Human HEK293 Cells
FGFR2 Protein, Human, Recombinant (alpha(IIIb), His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 42.88 kDa and the accession number is NP_075259.4.
TMPY-01228 FGFR2 Protein, Human, Recombinant (aa 1-377, His)

TK14,CEK3,BEK,BBDS,CD332,TK

Human HEK293 Cells
FGFR2 Protein, Human, Recombinant (aa 1-377, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 41 kDa and the accession number is P21802-1.
TMPK-00396 FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

BFR-1,FGF R2a,TK25,TK14,BEK,BBDS,...

 Human HEK293 Cells
FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42.5 kDa and the accession number is P21802-1.

重组蛋白

FGFR2 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00972
Species: Human
Expression System: HEK293 Cells
FGFR2 Protein, Human, Recombinant (alpha IIIb, hFc)
Cat.No: TMPY-00423
Species: Human
Expression System: HEK293 Cells
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)
Cat.No: TMPK-00398
Species: Human
Expression System: HEK293 Cells
FGFR2 beta (IIIb) Protein, Mouse, Recombinant (His)
Cat.No: TMPK-00847
Species: Mouse
Expression System: HEK293 Cells
FGFR2 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00397
Species: Human
Expression System: HEK293 Cells
FGFR2 beta (IIIb) Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00475
Species: Cynomolgus
Expression System: HEK293 Cells
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00400
Species: Human
Expression System: HEK293 Cells
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated
Cat.No: TMPK-00399
Species: Human
Expression System: HEK293 Cells
FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00401
Species: Human
Expression System: HEK293 Cells
FGFR2 Protein, Human, Recombinant (beta IIIc, His)
Cat.No: TMPY-00351
Species: Human
Expression System: HEK293 Cells
FGFR2 Protein, Human, Recombinant (aa 1-378, His)
Cat.No: TMPY-04273
Species: Human
Expression System: HEK293 Cells
FGFR2 Protein, Human, Recombinant (aa 400-821, His & GST)
Cat.No: TMPY-04390
Species: Human
Expression System: Baculovirus Insect Cells
FGFR2 Protein, Human, Recombinant (alpha(IIIb), His & Avi), Biotinylated
Cat.No: TMPY-06321
Species: Human
Expression System: HEK293 Cells
FGFR2 Protein, Human, Recombinant (aa 1-377, His)
Cat.No: TMPY-01228
Species: Human
Expression System: HEK293 Cells
FGFR2 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00396
Species: Human
Expression System: HEK293 Cells
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