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Cat. No. | Product Name | Target | Signaling Pathways |
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T40463 |
Relacatib
SB-462795 |
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Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib's inhibitory effect on bone resorption in ... | |||
T75891 |
α-Helical CRF(9-41) TFA
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α-Helical CRF(9-41) TFA 是一种竞争性 CRF2受体拮抗剂,KB 约为 100 nM。α-Helical CRF(9-41) TFA 也是一种 CRF1受体的部分激动剂,EC50为 140 nM。 | |||
T61514 | Enpp-1-IN-12 | ||
Enpp-1-IN-12 (化合物 43) 是一种有效和具有口服活性的外核苷酸焦磷酸酶/磷酸二酯酶 1 (ENPP1) 抑制剂,Ki 值 41 nM。Enpp-1-IN-12 具有抗肿瘤活性。 | |||
T81081 |
Stressin I TFA
Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41) TFA |
CRFR | GPCR/G Protein |
Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA,作为CRF1受体选择性激动剂,具有1.7 nM的Ki值。该化合物能够促使大鼠促肾上腺皮质激素(ACTH)水平提升。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T25563 |
K 41
K-41,K41,Antibiotic K-41A,37454 RP,Antibiotic A 32887 |
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K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus. | |||
T35624 |
Ajoene
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Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces... |