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14

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3680	ISO-1 MIF Antagonist,ISO 1	Others	Others
	ISO-1 (MIF Antagonist) 是一种巨噬细胞移动抑制因子(MIF) 拮抗剂(IC50:7 μM)。
T7501	Iso-H7 dihydrochloride 1-(5-硫代异喹啉)-3-甲基哌嗪二盐酸盐	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	与 H-7 相比，Iso-H7 dihydrochloride 是一种较弱的磷酸激酶 C 抑制剂。
T30360	2-(3-iso-Propylphenyl)-2-propanol Benzenemethanol, alpha,alpha-dimethyl-3-(1-methylethyl)- (9CI)
	Benzenemethanol, alpha,alpha-dimethyl-3-(1-methylethyl)- (9CI) is a bioactive chemical.
T64363	(Iso)-RJW100	Others	Others
	(Iso)-RJW100 是一种有效的肝受体同源物 1 (LRH-1，NR5A2) 和类固醇生成因子-1 (SF-1，NR5A1) 激动剂，pEC50 分别为 6.4 和 7.2。
T36164	8-iso Prostaglandin F3α 8-iso Prostaglandin F3α,8-epi PGF3α
	8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 uM. [1]
T18313	Mc-O-Si(di-iso)-Cl	Others	Others
	Mc-O-Si(di-iso)-Cl is a cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs) like Gemcitabine-O-Si(di-iso)-O-Mc [1].
T78099	iso-TRAP-6 iso-SFLLRN
	iso-TRAP-6(iso-SFLLRN)为PAR-1激动剂，具备激活血小板的能力。该化合物作为TRAP-6的同系物，通过以异丝氨酸替换丝氨酸成为首位氨基酸而构成。
T36166	8-iso-15-keto Prostaglandin F2α 8-iso-15-keto Prostaglandin F2α
	8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the in...
T36161	8-iso Prostaglandin E2 isopropyl ester 8-iso Prostaglandin E2 isopropyl ester
	8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of prostaglandins show greatly diminished agonist activity in vitro compared to the parent free acids.
T17985	Gemcitabine-O-Si(di-iso)-O-Mc	Others	Others
	Gemcitabine-O-Si(di-iso)-O-Mc, a drug-linker conjugate for Antibody-Drug Conjugates (ADC), exhibits potent antitumor activity. It incorporates Gemcitabine, a pyrimidine nucleoside analog antimetabolite and antineoplastic agent, connected through the ADC linker[1].
T18369	N-(5-Hydroxypentyl)maleimide	Others	Others
	N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a crucial component in the production of Gemcitabine-O-Si(di-iso)-O-Mc, an ADC compound [1].
T75049	3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine
	3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂，也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate，Acadesine ，Clofarabine ，Fludarabine phosphate 和 Vidarabine 。
T83662	2,3-dinor-8-iso Prostaglandin F1α 2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP
	2,3-dinor-8-iso Prostaglandin F1α（2,3-dinor-8-iso PGF1α）是一种异前列腺素和花生四烯酸的活性代谢物，也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩（EC50s分别为12.8和18.5 nM），但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时，它能增加孤立的猪大脑切片中的血栓素B2（TXB2）水平，这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体（nAChR）拮抗剂α-conotoxin来逆转。
T38081	Tunicamycin 14:1 Mixture
	Tunicamycin 14:1 is a mixture of tunicamycin structural isomers that contain a 14-carbon N-acyl chain with variable branching patterns. The N-acyl chain incorporated into tunicamycins, like tunicamycin 14:1, is derived from the same pool of cellular branched-chain fatty acids (BCFAs) in Streptomyces and directly impacts the biological activity of each individual tunicamycin variant.1,2,3Purified tunicamycin 14:1 with the iso branching configuration inhibits bacterial phospho-MurNAc-pentapeptide ...

化合物

Cat.No: T3680

Synonym: MIF Antagonist,ISO 1

Target: Others

Iso-H7 dihydrochloride

Cat.No: T7501

Synonym: 1-(5-硫代异喹啉)-3-甲基哌嗪二盐酸盐

Target: PKC

2-(3-iso-Propylphenyl)-2-propanol

Cat.No: T30360

Synonym: Benzenemethanol, alpha,alpha-dimethyl-3-(1-methylethyl)- (9CI)

Cat.No: T64363

Target: Others

8-iso Prostaglandin F3α

Cat.No: T36164

Synonym: 8-iso Prostaglandin F3α,8-epi PGF3α

Mc-O-Si(di-iso)-Cl

Cat.No: T18313

Target: Others

Cat.No: T78099

Synonym: iso-SFLLRN

8-iso-15-keto Prostaglandin F2α

Cat.No: T36166

Synonym: 8-iso-15-keto Prostaglandin F2α

8-iso Prostaglandin E2 isopropyl ester

Cat.No: T36161

Synonym: 8-iso Prostaglandin E2 isopropyl ester

Gemcitabine-O-Si(di-iso)-O-Mc

Cat.No: T17985

Target: Others

N-(5-Hydroxypentyl)maleimide

Cat.No: T18369

Target: Others

3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine

Cat.No: T75049

2,3-dinor-8-iso Prostaglandin F1α

Cat.No: T83662

Synonym: 2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP

Tunicamycin 14:1 Mixture

Cat.No: T38081

Cat. No.	Product Name	Target	Signaling Pathways
T83419	1α-Hydroxy-3-deoxypseudoanisatin
	1α-Hydroxy-3-deoxypseudoanisatin (Iso-γ-fagarine) 是倍半萜类化合物，可从八角(Illicium merrillianum)果皮中分离。
T80680	γ-Isofagarine Iso-γ-fagarine
	Isofagarine (Iso-γ-fagarine) 为一生物碱，源自Dictamnus angustifolius根皮。该化合物参与风湿、出血、瘙痒、黄疸、慢性肝炎和皮肤病等病态研究。

天然产物

1α-Hydroxy-3-deoxypseudoanisatin

Cat.No: T83419

γ-Isofagarine

Cat.No: T80680

Synonym: Iso-γ-fagarine

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