18
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3680 |
ISO-1
MIF Antagonist,ISO 1 |
Others | Others |
ISO-1 (MIF Antagonist) 是一种巨噬细胞移动抑制因子(MIF) 拮抗剂(IC50:7 μM)。 | |||
T7501 |
Iso-H7 dihydrochloride
1-(5-硫代异喹啉)-3-甲基哌嗪二盐酸盐 |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
与 H-7 相比,Iso-H7 dihydrochloride 是一种较弱的磷酸激酶 C 抑制剂。 | |||
T30360 |
2-(3-iso-Propylphenyl)-2-propanol
Benzenemethanol, alpha,alpha-dimethyl-3-(1-methylethyl)- (9CI) |
||
Benzenemethanol, alpha,alpha-dimethyl-3-(1-methylethyl)- (9CI) is a bioactive chemical. | |||
T36157 |
8-iso Prostaglandin A1
8-iso Prostaglandin A1 |
||
8-iso Prostaglandin A1 (8-iso PGA1) is an isoprostane and a member in a large family of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature. | |||
T36163 |
8-iso Prostaglandin F1β
8-iso Prostaglandin F1β |
||
8-iso PGF1β is a potential autoxidation product of DGLA. There are no published reports on its isolation from any biological source or on its biological activity. | |||
T36159 |
8-iso Prostaglandin E1
8-iso Prostaglandin E1 |
||
8-iso Prostaglandin E1 能引起犬肺静脉中的痉挛,还能够起到血管舒张作用。 | |||
T36162 |
8-iso Prostaglandin F1α
8-iso Prostaglandin F1α |
||
8-iso PGF1α is an isoprostane that was first identified in human semen. It is a member of the isoprostane family, which are eicosanoids of non-cyclooxygenase origin. 8-iso PGF1α is present along with its 19-hydroxy congener at 5-10 μg/ml of seminal plasma. | |||
T83662 |
2,3-dinor-8-iso Prostaglandin F1α
2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP |
||
2,3-dinor-8-iso Prostaglandin F1α(2,3-dinor-8-iso PGF1α)是一种异前列腺素和花生四烯酸的活性代谢物,也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩(EC50s分别为12.8和18.5 nM),但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时,它能增加孤立的猪大脑切片中的血栓素B2(TXB2)水平,这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体(nAChR)拮抗剂α-conotoxin来逆转。 | |||
T64363 |
(Iso)-RJW100
|
Others | Others |
(Iso)-RJW100 是一种有效的肝受体同源物 1 (LRH-1,NR5A2) 和类固醇生成因子-1 (SF-1,NR5A1) 激动剂,pEC50 分别为 6.4 和 7.2。 | |||
T36164 |
8-iso Prostaglandin F3α
8-iso Prostaglandin F3α,8-epi PGF3α |
||
8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 uM. [1] | |||
T18313 |
Mc-O-Si(di-iso)-Cl
|
Others | Others |
Mc-O-Si(di-iso)-Cl is a cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs) like Gemcitabine-O-Si(di-iso)-O-Mc [1]. | |||
T78099 |
iso-TRAP-6
iso-SFLLRN |
||
iso-TRAP-6(iso-SFLLRN)为PAR-1激动剂,具备激活血小板的能力。该化合物作为TRAP-6的同系物,通过以异丝氨酸替换丝氨酸成为首位氨基酸而构成。 | |||
T36166 |
8-iso-15-keto Prostaglandin F2α
8-iso-15-keto Prostaglandin F2α |
||
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the in... | |||
T36161 |
8-iso Prostaglandin E2 isopropyl ester
8-iso Prostaglandin E2 isopropyl ester |
||
8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of prostaglandins show greatly diminished agonist activity in vitro compared to the parent free acids. | |||
T17985 |
Gemcitabine-O-Si(di-iso)-O-Mc
|
Others | Others |
Gemcitabine-O-Si(di-iso)-O-Mc, a drug-linker conjugate for Antibody-Drug Conjugates (ADC), exhibits potent antitumor activity. It incorporates Gemcitabine, a pyrimidine nucleoside analog antimetabolite and antineoplastic agent, connected through the ADC linker[1]. | |||
T18369 |
N-(5-Hydroxypentyl)maleimide
|
Others | Others |
N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs). It serves as a crucial component in the production of Gemcitabine-O-Si(di-iso)-O-Mc, an ADC compound [1]. | |||
T75049 | 3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine | ||
3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂,也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate,Acadesine ,Clofarabine ,Fludarabine phosphate 和 Vidarabine 。 | |||
T38081 |
Tunicamycin 14:1 Mixture
|
||
Tunicamycin 14:1 is a mixture of tunicamycin structural isomers that contain a 14-carbon N-acyl chain with variable branching patterns. The N-acyl chain incorporated into tunicamycins, like tunicamycin 14:1, is derived from the same pool of cellular branched-chain fatty acids (BCFAs) in Streptomyces and directly impacts the biological activity of each individual tunicamycin variant.1,2,3Purified tunicamycin 14:1 with the iso branching configuration inhibits bacterial phospho-MurNAc-pentapeptide ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83419 |
1α-Hydroxy-3-deoxypseudoanisatin
|
||
1α-Hydroxy-3-deoxypseudoanisatin (Iso-γ-fagarine) 是倍半萜类化合物,可从八角(Illicium merrillianum)果皮中分离。 | |||
T80680 |
γ-Isofagarine
Iso-γ-fagarine |
||
Isofagarine (Iso-γ-fagarine) 为一生物碱,源自Dictamnus angustifolius根皮。该化合物参与风湿、出血、瘙痒、黄疸、慢性肝炎和皮肤病等病态研究。 |