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Search Results for " ire1a "

Targets Recommended: IRE1

4

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9564	IRE1α kinase-IN-1	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM)，对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化，并抑制 IRE1α RNase 活性 (IC50=80 nM)。
T38841	IRE1α kinase-IN-2 IRE1α kinase-IN-2
	IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM. It effectively impedes IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. Additionally, IRE1α kinase-IN-2 effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.
T40336	IRE1α kinase-IN-6 IRE1α kinase-IN-6
	IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.
T9848	GSK2850163 (S enantiomer)	IRE1	Cell Cycle/Checkpoint
	GSK2850163 (S enantiomer) 是 GSK2850163 的无活性对映体。GSK2850163 是一种新型的肌醇需求酶-1α (IRE1a) 抑制剂。

化合物

IRE1α kinase-IN-1

Cat.No: T9564

Target: IRE1

IRE1α kinase-IN-2

Cat.No: T38841

Synonym: IRE1α kinase-IN-2

IRE1α kinase-IN-6

Cat.No: T40336

Synonym: IRE1α kinase-IN-6

GSK2850163 (S enantiomer)

Cat.No: T9848

Target: IRE1

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04413	IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) hIRE1p,endoplasmic reticulum to nucleus signaling 1...	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces...
TMPY-04753	IRE1 Protein, Human, Recombinant (aa 465-977) hIRE1p,endoplasmic reticulum to nucleus signaling 1...	Human	Baculovirus-Insect Cells
	Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces...

重组蛋白

IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)

Cat.No: TMPY-04413

Species: Human

Expression System: Baculovirus-Insect Cells

IRE1 Protein, Human, Recombinant (aa 465-977)

Cat.No: TMPY-04753

Species: Human

Expression System: Baculovirus-Insect Cells

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