Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11623 |
IDO/TDO-IN-1
|
Others | Others |
IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM). | |||
T61385 |
IDO1/TDO-IN-1
|
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IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhibits a significant capacity to induce cell apoptosis via the potential mitochondria-mediated Bcl-2/Bax pathway [1]. | |||
T72056 |
KYN-101
|
||
KYN-101是一种高效、选择性的芳香烃受体(AHR)合成拮抗剂,在人HepG2 DRE 荧光素酶报告基因检测中IC50为22 nM,在小鼠Hepa1 Cyp-luc 检测中IC50为23 nM。KYN-101逆转IDO/TDO 介导的肿瘤进展,提高PD-1阻断B16 IDO 荷瘤小鼠和表达内源性高水平IDO 的CT26结直肠癌模型的疗效。 | |||
T74536 | IDO/Tubulin-IN-2 | ||
IDO/Tubulin-IN-2 (HT2) 是一种对TDO和微管蛋白 (tubulin)展现出高效抑制作用的化合物。该抑制剂对多种癌细胞系(包括U87、HepG2、A549、HCT-116和LO2)均表现出强抗肿瘤活性,其半抑制浓度(IC50)分别为0.43、0.036、0.041、0.095和1.04 μM,有效提升了抗肿瘤效果。 |