Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2044L |
α-CGRP (human) acetate
人类降钙素基因相关肽 1,α-CGRP (human) acetate (90954-53-3 free base) |
Others | Others |
α-CGRP (human) acetate 是一种由 37 个氨基酸组成的调节性神经肽。它是一种有效的血管扩张剂,具有正性肌力作用和变时性作用。 | |||
TP2044 |
α-CGRP(human)
α-CGRP (human) |
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Endogenous calcitonin gene-related peptide receptor (CGRP) agonist. | |||
TP1134 |
HCGRP-(8-37)
Human α-CGRP (8-37) |
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Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist | |||
T36555 |
Tyr-α-CGRP (human) (trifluoroacetate salt)
|
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Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide . It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively). Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM). It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated rig... | |||
TP1134L |
HCGRP-(8-37) acetate
HCGRP-(8-37) acetate (119911-68-1 free base) |
CGRP Receptor | GPCR/G Protein; Neuroscience |
HCGRP-(8-37) acetate 是一种人降钙素基因相关肽 (hCGRP) 片段醋酸盐,也是 CGRP 受体的拮抗剂。 | |||
T76874 |
Erenumab
AMG-334 |
CGRP Receptor | GPCR/G Protein; Neuroscience |
Erenumab是一种全人单克隆抗体,作用于抑制降钙素基因相关肽(CGRP)受体,用于预防发作性偏头痛。 | |||
TP1130 |
β-CGRP, human
CGRP-II (Human),Human β-CGRP |
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β-CGRP, human ,a 37-amino acid peptide,is the beta form of Calcitonin-gene-related peptide (β-CGRP), involved extensively in regulation of the cardiovascular and nervous systems. β-CGRP contains a disulphide bridge at the N-terminus, a C-terminal phenylal | |||
T75978 |
β-CGRP, human TFA
|
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β-CGRP, human TFA (Human β-CGRP TFA) 是一种降钙素肽,通过降钙素受体样受体CRLR 与RAMP 的复合物起作用,在细胞体系中,对 CRLR/RAMP1 和 CRLR/RAMP2 的IC50值分别为 1 nM 和 300 nM。 | |||
T12293 |
Olcegepant hydrochloride
BIBN-4096 hydrochloride,BIBN4096BS hydrochloride |
Others | Others |
Olcegepant hydrochloride is a potent and selective non-peptidethe calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (with IC50 of 0.03 nM for human CGRP). | |||
T21558 |
MK-3207
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MK-3207是口服生物相容性的CGRP 受体拮抗剂,IC50和 Ki 分别为 0.12 nM 和 0.024 nM,对 AM1,AM2,CTR 和 AMY3 的抑制性较弱。MK-3207可用于偏头痛研究。 | |||
T6590 |
MK-3207 Hydrochloride
MK-3207 HCl |
CGRP Receptor | GPCR/G Protein; Neuroscience |
MK-3207 Hydrochloride (MK-3207 HCl) 是口服具有活力的CGRP receptor 拮抗剂,IC50=0.12 nM,Ki=0.024 nM。 | |||
T75788 |
α-CGRP(human) TFA
|
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α-CGRP(human) TFA,一种含37个氨基酸的调节性神经肽,广泛存在于中枢神经系统和周围神经系统中,是一种高效的血管扩张剂。 | |||
T76473 |
Adrenotensin (human)
|
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Adrenotensin (human) (Pro-ADM-153-185 (human)) 是一种肾上腺髓质素前体肽的特定片段,具体为153至185位点。Adrenotensin (ADM)作为一个含有52个氨基酸的多功能肽,隶属于血管活性肽激素CGRP超家族。 | |||
T76678 | Eptinezumab | ||
Eptinezumab为人源化单克隆抗体,主要通过与降钙素基因相关肽(CGRP)结合,进而阻止其与受体相结合,用于成人偏头痛的预防。 |