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2

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T41365	12S-HHT

T70446	Abivertinib HCl
	Abivertinib, also known as AC0010 and Avitinib, is a third-generation EGFR tyrosine kinase inhibitor and BTK Inhibitor that demonstrated clinical efficacy and manageable adverse events (AEs). Abivertinib inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AML cells, especially those harboring FLT3-ITD mutations. Abivertinib was also found to be more sensitive than ibrutinib in treating AML. Abivertinib may be a promising novel agent for A...

化合物

Cat.No: T41365

Abivertinib HCl

Cat.No: T70446

Cat. No.	Product Name	Target	Signaling Pathways
T3380	Homoharringtonine Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate	STAT	JAK/STAT signaling; Stem Cells
	Homoharringtonine (HHT) 属于生物碱类天然产物，可以抑制蛋白质的翻译，具有细胞毒性。Homoharringtonine 作用于肿瘤细胞的核糖体，抑制蛋白质翻译的延伸步骤，从而抑制蛋白质合成，具有抗肿瘤活性。
T2964	2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside 芪多酚,2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols	Others	Others
	2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) 是分离自蓼属植物物种的根中，对5-HETE、HHT、thromboxane B2的形成具有抑制作用。
TN1957	Mulberrofuran Q MulberrofuranQ
	Mulberrofuran Q是一种有活性的化合物，可抑制12-羟基-5,8,10-十七碳三烯酸(HHT)和血栓烷B2(环加氧酶产物)的形成，可保护神经细胞免受缺氧-缺糖（OGD）诱导的氧化应激的影响。
T4740	Elaidic acid 反油酸,trans-Oleic Acid	Endogenous Metabolite	Metabolism
	Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪，能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中，反油酸抑制 HHT 和 HETE 的形成，同时诱导前列腺素和血栓素的合成。
TN4586	Mulberrofuran A	COX	Immunology/Inflammation; Neuroscience
	Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE).

天然产物

Homoharringtonine

Cat.No: T3380

Synonym: Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate

Target: STAT

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside

Cat.No: T2964

Synonym: 芪多酚,2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols

Target: Others

Mulberrofuran Q

Cat.No: TN1957

Synonym: MulberrofuranQ

Cat.No: T4740

Synonym: 反油酸,trans-Oleic Acid

Target: Endogenous Metabolite

Mulberrofuran A

Cat.No: TN4586

Target: COX

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