Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60794 | HDAC10-IN-1 | ||
HDAC10-IN-1 (化合物 13b) 是一种有效且高选择性的HDAC10抑制剂 (IC 50 = 58 nM),可用于调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。 | |||
T78145 |
HDAC10-IN-2 hydrochloride
|
Autophagy | Autophagy |
HDAC10-IN-2 hydrochloride(化合物10c)是一种对HDAC10具有高效性和高选择性的抑制剂,IC50值为20 nM。该化合物能够调控FLT3-ITD阳性急性髓系白血病细胞的自噬过程。 | |||
T60760 |
HDAC10-IN-2
|
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HDAC10-IN-2 (化合物 10c) 调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。HDAC10-IN-2是HDAC10的高选择性抑制剂 (IC50 = 20 nM)。 | |||
T60856 |
HDAC6-IN-9
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HDAC6-IN-9 (compound 12c) 是 HDAC6的强效选择性抑制剂,具有抗增殖活性。HDAC6-IN-9 对 HDAC6、HDAC1、HDAC3、HDAC8 和 HDAC10 的 IC50值分别为 4.2, 11.8, 15.2, 139.6, 21.3 nM。 | |||
T61139 | HDAC6-IN-3 | ||
HDAC6-IN-3 (Compound 14) is a potent anti-prostate cancer agent that acts as an orally active inhibitor of HDAC6. It has IC50 values ranging from 0.02-1.54 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10. Additionally, HDAC6-IN-3 also demonstrates effective inhibition of MAO-A (IC50 = 0.79 μM) and LSD1 [1]. | |||
T35762 | MC1742 | ||
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin... | |||
T38381 |
CAY17c
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CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620,... |