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1

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T70280	KB-R7785
	KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the inhibition of TNF-alpha production.

化合物

Cat.No: T70280

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01286	proHB-EGF Protein, Human, Recombinant (His) heparin-binding EGF-like growth factor,HB-...	Human	HEK293 Cells
	Heparin-binding EGF-like growth factor (HB-EGF) is a 1216 kDa member of the epidermal growth factor (EGF) family. It possesses an EGFlike domain, and a heparin-binding motif. Mature HBEGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HBEGF shows 76% and 73% aa sequence identity with rat and mouse HBEGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may b...
TMPY-02246	HB-EGF Protein, Human, Recombinant DTSF,DTR,HEGFL,heparin-binding EGF-like gr...	Human	Baculovirus Insect Cells
	Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HBEGF activates two EGF receptor subtypes, HER1 and HER4, and binds to cell surface HSPG. The transmembrane form of...
TMPJ-00058	BTC Protein, Mouse, Recombinant (His) βcellulin,isoform CRA_a,Btc,Betacellulin,mCG_12529	Mouse	E. coli
	Mouse Betacellulin is a single type I membrane protein which belongs to the EGF family of cytokines. EGF family has many members including EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. Betacellulin is characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin is expressed in several tissues and tumor cells including kidney, uterus, liver, pancreas and small intestine....
TMPY-01212	ADAM12 Protein, Human, Recombinant (His) ADAM metallopeptidase domain 12,MLTNA,MCMP,CAR10,MLTN,MCMPMl...	Human	HEK293 Cells
	The ADAMs (a disintegrin and metalloprotease) comprise a family of multidomain proteins with metalloprotease, cell adhesion, and signaling activities. Human ADAM12, which is implicated in diseases such as cancer, is expressed in two splice forms, the transmembrane ADAM12-L and the shorter and soluble ADAM12-S. ADAM12, also known as and Meltrin alpha, is a member of the ADAM protein family, which contains one disintegrin domain, one EGF-like domain and one peptidase M12B domain. ADAM12 is synthes...

重组蛋白

proHB-EGF Protein, Human, Recombinant (His)

Cat.No: TMPJ-01286

Species: Human

Expression System: HEK293 Cells

HB-EGF Protein, Human, Recombinant

Cat.No: TMPY-02246

Species: Human

Expression System: Baculovirus Insect Cells

BTC Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00058

Species: Mouse

Expression System: E. coli

ADAM12 Protein, Human, Recombinant (His)

Cat.No: TMPY-01212

Species: Human

Expression System: HEK293 Cells

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