Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5829 |
H4 Receptor antagonist 1
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
H4 Receptor antagonist 1 是选择性组胺 H4受体反向激动剂,其IC50值为19 nM。 | |||
T38634 |
Histamine H4 receptor antagonist-1
Histamine H4 receptor antagonist-1 |
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Histamine H4 receptor antagonist-1 is a potent antagonist of the histamine H4 receptor. | |||
T11532 |
H4R antagonist 1
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
H4R antagonist 1 is a highly selective histamine H4 receptor (H4R) antagonist (IC50: 27 nM). H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R. | |||
T79786 |
H4R antagonist 2
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
H4R antagonist 2 是Furo[3,2-d]嘧啶衍生的有效H4R拮抗剂,主要用于类风湿性关节炎的研究。 | |||
T61011 | Izuforant | ||
Izuforant (JW1601) (Compound 24) 具有有效的抗炎和止痒活性。 Izuforant 对人血清素3受体 (h5-HT3R) 具有结合亲和力,IC50值为 9.1 μM。它也是组胺 H4 受体 (H4R) 的口服活性拮抗剂,对人 H4R 的IC50值为 36 nM。 | |||
T38323 |
A-943931 (hydrochloride hydrate)
|
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A-943931 is a histamine H4receptor antagonist (Ki= 3.8 nM).1In vivo, A-943931 inhibits scratching induced by clobenpropit in mice (ED50= 26 μmoles/kg, i.p.). 1.Milicic, I., Witte, D.G., Miller, T.L., et al.Identification of two potent and selective histamine H4 receptor antagonists with antipruritic activityFASEB J.23(S1)760.768-760.768(2009) |