Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11631 |
iFSP1
|
Ferroptosis | Apoptosis |
iFSP1 是一种强效、选择性和谷胱甘肽独立的铁死亡抑制蛋白 1 (FSP1) (AIFM2) 抑制剂,具有EC50 为 103 nM。它能够使多种人类癌细胞系对铁死亡诱导剂敏感,例如 (1S,3R)-RSL3。它在过表达 FSP1 的 GPX4 敲除细胞中选择性地诱导铁死亡。 | |||
T37487 |
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
|
||
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3. |