Cat. No. | Product Name | Target | Signaling Pathways |
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T62898 |
Glucosylceramide synthase-IN-1
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Glucosylceramide synthase-IN-1 (T-036) 是一种有效的、口服具有活力的、具有血脑屏障通透性的 glucosylceramide synthase (GCS) 抑制剂,作用于人 GCS (IC50: 31 nM) 和小鼠 GCS (IC50: 51 nM)。Glucosylceramide synthase-IN-1 能够用于研究戈谢病。 | |||
T3663 |
Eliglustat
GENZ-112638,Genz 99067,依利格鲁司特 |
Transferase | Metabolism |
Eliglustat (Genz 99067) 是一种高效的、特异性的、有口服活性的葡糖脑苷脂合成酶抑制剂(IC50:24 nM)。 | |||
T4473 |
Ibiglustat
Venglustat,SAR402671,GZ402671 |
Transferase | Metabolism |
Ibiglustat (GZ402671) 是一种可透过血脑屏障的、具有口服活性的葡萄糖神经酰胺合成酶(GCS)抑制剂。它可用于戈谢病 3 型、法布瑞氏症、与 GBA 突变相关的帕金森病、GM2 神经节苷脂病和常染色体显性多囊肾病的研究。 | |||
T61632 | Glucosylceramide synthase-IN-3 | ||
Glucosylceramide synthase-IN-3 (compound BZ1) is a highly potent, brain-penetrant, and orally active inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 value of 16 nM for human GCS. This compound, designated as Glucosylceramide synthase-IN-3, finds potential applications in Gaucher's disease research [1] [2]. | |||
T73716 |
Miglustat-d9 HCl
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Miglustat-d9 (hydrochloride)为Miglustat (hydrochloride)的氘代物,属于葡萄糖神经酰胺合成酶抑制剂,主要用于治疗I型戈谢病。 | |||
T36974 |
D-threo-PPMP hydrochloride
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D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(201... |