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抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T27029 cjoc42

cjoc 42,cjoc-42

Cjoc42 是gankyrin 的抑制剂, 以剂量依赖性方式抑制 gankyrin 活性。它可防止 p53 蛋白水平的降低。它恢复 p53 依赖性转录和对 DNA 损伤的敏感性。

化合物

cjoc42
Cat.No: T27029
Synonym: cjoc 42,cjoc-42
Target:
Cat. No. Product Name Species Expression System
TMPJ-00703 Gankyrin Protein, Human, Recombinant

PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulator...

Human E. coli
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.

重组蛋白

Gankyrin Protein, Human, Recombinant
Cat.No: TMPJ-00703
Species: Human
Expression System: E. coli
TargetMol Loading
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