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Cat. No. | Product Name | Target | Signaling Pathways |
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T27029 |
cjoc42
cjoc 42,cjoc-42 |
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Cjoc42 是gankyrin 的抑制剂, 以剂量依赖性方式抑制 gankyrin 活性。它可防止 p53 蛋白水平的降低。它恢复 p53 依赖性转录和对 DNA 损伤的敏感性。 |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00703 |
Gankyrin Protein, Human, Recombinant
PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulator... |
Human | E. coli |
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis. |