Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6310 |
GW3965 hydrochloride
GW3965 HCl |
Liver X Receptor | Metabolism |
GW3965 hydrochloride (GW3965 HCl) 是一种肝 X 受体 (LXR) 激动剂,主要作用于 hLXRα (EC50:190 nM) 和 hLXRβ (EC50:30 nM) | |||
T6310L |
GW3965
|
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GW3965 是选择性的肝 X 受体 (LXR) 激动剂,对 hLXRα 和 hLXRβ 的 EC50分别为 190 nM 和 30 nM。 | |||
T75388 | FITC-GW3965 | ||
FITC-GW3965 是一种荧光标记的肝脏 X 受体 β (LXRβ) 激动剂 GW3965 。FITC-GW3965 是一种示踪剂,可以通过用酰胺取代 GW3965 的三氟甲基来连接 FITC 而设计得到。FITC-GW3965 可用于研究 LXRβ 的功能。 | |||
T36130 |
22(S)-hydroxy Cholesterol
22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol |
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22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22... |