Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9573 |
GSK3685032
|
DNA Methyltransferase | Chromatin/Epigenetic |
GSK-3685032 是一种非时间依赖、非共价、选择性的、可逆的DNMT1抑制剂,IC50=0.036 μM。它诱导 DNA 甲基化丧失、转录激活和癌细胞生长抑制。 | |||
T39648 |
(R)-GSK-3685032
|
||
(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a first-in-class, non-time-dependent, non-covalent, reversible, selective DNMT1 inhibitor with an IC 50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation and inhibition of cancer cell growth. |