Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5745 |
GSK3326595
EPZ015938 |
Histone Methyltransferase | Chromatin/Epigenetic |
GSK3326595 (EPZ015938) 是一种选择性可逆的蛋白精氨酸甲基转移酶 5 抑制剂,IC50为6.2 nM,具有广谱的抗增殖活性。 | |||
T70124 | Tomivosertib HCl | ||
Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling. |