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Cat. No. | Product Name | Target | Signaling Pathways |
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T82261 |
Grb2 SH2 domain inhibitor 1
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Grb2 SH2 domain inhibitor 1是构象受限环细胞穿透肽(CPP),主要用作环状肽基抑制剂,包含特定d-Pro-l-Pro基序环(AFΦrpPRRFQ),其中Φ为l-萘基丙氨酸,r为d-精氨酸,p为d-脯氨酸。 | |||
T77994 |
Grb2 SH2 domain inhibitor 1 TFA
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Grb2 SH2 domain inhibitor 1 TFA 是构象受限的环细胞穿透肽(CPP),含有d-Pro-l-Pro基序环(AFΦrpPRRFQ),Φ为l-萘基丙氨酸,r为d-精氨酸,p为d-脯氨酸,主要用作环状肽基抑制剂。 | |||
T40219 |
CGP78850
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CGP78850 is a potent and selective Grb2 SH2-phosphopeptide interaction antagonist that holds potential for cancer research. | |||
T37422 |
Ras Inhibitory Peptide
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Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction ... | |||
T36878 |
Sclerotiorin
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Sclerotiorin is a natural product isolated primarily from Penicillium species. It inhibits soybean lipoxygenase-1 with an IC50 value of 4.2 μM. Sclerotiorin also exhibits a number of other activities including inhibition of cholesterol ester transfer protein (IC50 = 19.4 μM),, inhibition of Grb2-Shc interaction (IC50 = 22 μM),, and antagonism of endothelin receptors (IC50 = 114 and 152 μM for human ETA and ETB, respectively). |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-01050 |
GRB2 Protein, Human, Recombinant (His)
Growth Factor Receptor-Bound Protein 2,SH2... |
Human | E. coli |
As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted acti... | |||
TMPJ-00166 |
SCF Protein, Mouse, Recombinant
SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel... |
Mouse | E. coli |
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ... | |||
TMPH-01106 |
CD300LB Protein, Human, Recombinant (His)
CMRF35-like molecule 7,CD300LB,CMRF35A2,CD300b,TREM... |
Human | E. coli |
Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. CD300LB Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 18.8 kDa and the accession number is A8K4G0. | |||
TMPK-00457 |
HGFR/c-Met Protein, Human, Recombinant (His & Avi)
cMET,Met (c-Met),MET,HGF/SF receptor,SF receptor,RCCP2 |
Human | HEK293 Cells |
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ... | |||
TMPJ-01323 |
NTAL Protein, Human, Recombinant (His)
Williams-Beuren Syndrome Chromosomal Region 5 P,Membrane-Ass... |
Human | HEK293 Cells |
Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It may also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. ... | |||
TMPK-00499 |
HGFR/c-Met Protein, Cynomolgus, Recombinant (His)
MET,oncogene MET,cMET,SF receptor,HGF/SF receptor,AUTS9,Met ... |
Cynomolgus | HEK293 Cells |
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ... | |||
TMPJ-00894 |
SCF Protein, Rat, Recombinant (His)
Hematopoietic growth factor KL,Steel factor,Stem cell factor... |
Rat | E. coli |
Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase... |