Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21235 |
Alosetron
Lotronex,GR68755,GR-68755,GR 68755,阿洛司琼 |
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Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. | |||
T2525 |
Alosetron hydrochloride
Lotronex,盐酸阿洛司琼,GR 68755C,GR 68755,GR 68755X |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Alosetron hydrochloride (GR 68755) 是一种高选择性的 5-HT3 受体拮抗剂,可减轻清醒或麻醉犬直肠扩张的内脏伤害性效应,具有抗炎活性,用于肠易激综合征的研究。它阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化,IC50约为 55 nM。 |