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Cat. No. Product Name Target Signaling Pathways
T77755 GPX4-IN-5

GPX oxidation-reduction
GPX4-IN-5 是一种小分子共价 GPX4 抑制剂(IC50: 0.12 μM),具有抗肿瘤活性。GPX4-IN-5 可促使铁死亡,可用于预防和治疗三阴性乳腺癌 (TNBC)。
T37805 JKE-1716

JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . 1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)

化合物

GPX4-IN-5
Cat.No: T77755
Synonym:
Target: GPX
JKE-1716
Cat.No: T37805
Synonym:
Target:
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