Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11441 |
GNE-987
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and 4.4 nM, respectively). GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50: 0.03 | |||
T12798 |
(S)-GNE-987
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC). |