Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15397 |
GNE-049
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, respectively). | |||
T39352 | Piperidine-GNE-049-N-Boc | ||
Piperidine-GNE-049-N-Boc is a ligand that specifically binds to the target protein dCBP, enabling it to be degraded by a selective and potent heterobifunctional degrader, p300/CBP. |