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9

抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T11393 GET73

Gamma hydroxybutyric acid analogue,GET 73

GluR Neuroscience
GET73 (Gamma hydroxybutyric acid analogue) 是天然神经递质 γ-羟基丁酸的类似物。它对谷氨酸在海马的传递有显著的影响。它具有抗酒精和抗焦虑的作用。
T24146 HOCPCA

HOCPCA is an effective and selective ligand for the GHB binding sites that acts by binding with 27 times better affinity than GHB itself and crossing the blood-brain barrier in vitro and in vivo.
T69259 NCS-356 sodium

NCS-356 sodium is a GHB receptor agonist.
T71533 NCS-356 sodium monohydrate

NCS-356 sodium monohydrate is a GHB receptor agonist.
T29058 UMB68 sodium

UMB-68 sodium,UMB68,UMB-68,UMB 68

UMB-68 is a GHB receptor ligand with no affinity (IC(50) >100 microM) at GABA(A) or GABA(B) receptors.
T23473 trans-4-Hydroxycrotonic acid

Others Others
ligand of γ-hydroxybutyric acid (GHB) receptor
T39962 Valiloxibic acid

XWL-008,Acidum valiloxibicum

Valiloxibic acid is a prodrug of γ-Hydroxybutyric acid (GHB).GHB is a naturally occurring neurotransmitter and a psychoactive drug, it acts on the GHB receptor and is a weak agonist at the GABAB receptor.
T68181 NCS-356

NCS-356 is a GHB receptor agonist.
T37822 AR-C 141990 hydrochloride

Monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.

化合物

GET73
Cat.No: T11393
Synonym: Gamma hydroxybutyric acid analogue,GET 73
Target: GluR
HOCPCA
Cat.No: T24146
Synonym:
Target:
NCS-356 sodium
Cat.No: T69259
Synonym:
Target:
NCS-356 sodium monohydrate
Cat.No: T71533
Synonym:
Target:
UMB68 sodium
Cat.No: T29058
Synonym: UMB-68 sodium,UMB68,UMB-68,UMB 68
Target:
trans-4-Hydroxycrotonic acid
Cat.No: T23473
Synonym:
Target: Others
Valiloxibic acid
Cat.No: T39962
Synonym: XWL-008,Acidum valiloxibicum
Target:
NCS-356
Cat.No: T68181
Synonym:
Target:
AR-C 141990 hydrochloride
Cat.No: T37822
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T5273 2-Hydroxy-3-methylbutanoic acid

2-Hydroxy-3-methylbutyric acid,2-Hydroxyisovaleric Acid,2-羟基-3-甲基丁酸,(±)-2-Hydroxyisopentanoic Acid

Others; Endogenous Metabolite Metabolism; Others
2-Hydroxy-3-methylbutanoic acid ((±)-2-Hydroxyisopentanoic Acid) 是一种 GHB 的结构类似物,其中GHB 是一种中枢神经系统中发现的天然物质,也是一种神经药物。

天然产物

2-Hydroxy-3-methylbutanoic acid
Cat.No: T5273
Synonym: 2-Hydroxy-3-methylbutyric acid,2-Hydroxyisovaleric Acid,2-羟基-3-甲基丁酸,(±)-2-Hydroxyisopentanoic Acid
Target: Others, Endogenous Metabolite
TargetMol Loading
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