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Cat. No. | Product Name | Target | Signaling Pathways |
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T77076 |
Luspatercept
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Luspatercept (ACE-536) 是一种重组修饰的 ActRIIB 融合蛋白,与转化生长因子β超家族配体结合,通过与GDF11结合抑制Smad2/3信号通路,从而增加红细胞数量并促进红细胞前体成熟,用于贫血的研究。 |
Cat. No. | Product Name | Species | Expression System |
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TMPH-01413 |
GDF11 Protein, Human, Recombinant (His & SUMO)
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Human | E. coli |
Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. GDF11 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression... | |||
TMPJ-00713 |
GDF-11 Protein, Human, Recombinant
Growth/differentiation factor 11,Bone morphogenetic... |
Human | HEK293 Cells |
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The si... |