Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22794 |
G36
G-36 |
Estrogen Receptor/ERR | Endocrinology/Hormones |
G36是一种细胞可渗透的G 蛋白偶联雌激素受体(GPER/GPR30)的非甾体拮抗剂。G36抑制17β-雌二醇或GPER 选择性激动剂G-1的激活(IC50分别为112和165 nM)。G36对ERα或ERβ均无可检测的结合活性。G36通过GPER 阻断由雌激素触发的PI3K 的激活或钙动员,并且它通过雌激素或G-1而不是通过EGF 抑制ERK 的激活。 | |||
T80737 | ZG36 | ||
ZG36是一种人类Caseinolytic protease P(ClpP)激动剂,具有非选择性地降解呼吸链复合物和减少线粒体DNA的能力,从而导致线粒体功能衰竭及白血病细胞死亡。此外,ZG36能够抑制异种移植小鼠模型中急性髓细胞性白血病的发展。 | |||
T17857 |
DSPE-PEG36-mal
|
Others | Others |
DSPE-PEG36-mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18282 |
Mal-PEG36-NHS ester
|
Others | Others |
Mal-PEG36-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18404 |
N-Boc-PEG36-alcohol
|
Others | Others |
N-Boc-PEG36-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18190 |
m-PEG36-alcohol
|
Others | Others |
m-PEG36-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17511 |
Azido-PEG36-alcohol
|
Others | Others |
Azido-PEG36-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18191 |
m-PEG36-amine
|
Others | Others |
m-PEG36-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17432 |
Amino-PEG36-CH2-Boc
|
Others | Others |
Amino-PEG36-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17510 |
Azido-PEG36-acid
|
Others | Others |
Azido-PEG36-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18193 |
m-PEG36-Br
|
Others | Others |
m-PEG36-Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17577 |
Biotin-PEG36-acid
|
Others | Others |
Biotin-PEG36-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17433 |
Amino-PEG36-CONH-PEG36-acid
|
Others | Others |
Amino-PEG36-CONH-PEG36-acid is a polyethylene glycol (PEG)-based linker with amino and carboxylic acid functionalities. It finds utility in the synthesis of proteolysis targeting chimeras (PROTACs)[1]. | |||
T17430 |
Amino-PEG36-alcohol
|
Others | Others |
Amino-PEG36-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T77836 |
APN-PEG36-tetrazine
|
||
APN-PEG36-tetrazine是APN-PEG4-tetrazine的类似物,后者作为具有可降解(cleavable)特性的含四个单元PEG的ADC linker,应用于抗体偶联活性分子(ADC)的合成。 | |||
T18510 |
OPSS-PEG36-acid
|
Others | Others |
OPSS-PEG36-acid is a 36-unit PEG linker amenable to cleavage, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T17962 |
Fmoc-N-PEG36-acid
|
Others | Others |
Fmoc-N-amido-PEG36-acid is a polyethylene glycol (PEG)-based linker utilized in PROTAC synthesis. It has been designed specifically for constructing PROTACs, which are bifunctional molecules capable of recruiting target proteins to an E3 ubiquitin ligase for degradation[1]. | |||
T17723 |
Cbz-NH-PEG36-C2-acid
|
Others | Others |
Cbz-NH-PEG36-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18771 |
TCO-PEG36-acid
|
Others | Others |
TCO-PEG36-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17856 |
DSPE-PEG36-DBCO
|
Others | Others |
DSPE-PEG36-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17429 |
Amino-PEG36-acid
|
Others | Others |
Amino-PEG36-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18713 |
SPDP-PEG36-NHS ester
|
Others | Others |
SPDP-PEG36-NHS ester is a PEG ADC linker consisting of 36 units, characterized by cleavability. It plays a crucial role in the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T17678 | Boc-NH-PEG36-CH2CH2COOH | Others | Others |
Boc-NH-PEG36-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker employed for the synthesis of PROTACs[1]. | |||
T17512 |
Azido-PEG36-Boc
|
Others | Others |
Azido-PEG36-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17431 |
Amino-PEG36-Boc
|
Others | Others |
Amino-PEG36-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18195 |
m-PEG36-OH
|
Others | Others |
m-PEG36-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18194 |
m-PEG36-Mal
|
Others | Others |
m-PEG36-Mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17578 |
Biotin-PEG36-PFP ester
|
Others | Others |
Biotin-PEG36-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T18192 |
m-PEG36-azide
|
Others | Others |
m-PEG36-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |