Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11338 |
Furamidine
DB75,NSC 305831 |
Others | Others |
Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine (DB75) is abisbenzamidine derivative and an antiparasite agent. Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and ... | |||
T27395 |
Furamidine dihydrochloride
DB 75, DB75, NSC 305831, WR199385,Furamidine HCl |
||
Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site and is primarily competitive with t | |||
T16428 |
Pafuramidine
DB289 |
Others | Others |
Pafuramidine is an orally bioavailable prodrug of furamidine. It has activity against Pneumocystis pneumonia (IC50 value: 4.5 nM) | |||
T24587 |
Pafuramidine maleate
DB-289,DB289,DB 289 |
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Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis. | |||
T64372 |
DB722
|
Others | Others |
DB722是一种具有DNA 结合活性的呋喃脒类似物。DB722显示抗增殖活性。 |