Cat. No. | Product Name | Target | Signaling Pathways |
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T5841 |
Travoprost
曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药,是一种高亲和力的,选择性的 FP 前列腺素全受体激动剂。它能够降低眼压,有潜力应用于青光眼和眼高压。 | |||
T37813 |
Fluprostenol methyl ester
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Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug. CAY10532 is a methyl ester analog of fluprostenol. | |||
T37946 |
17-trifluoromethylphenyl trinor Prostaglandin F2α
17-trifluoromethylphenyl trinor Prostaglandin F2α |
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A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trin... | |||
T37948 |
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α |
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A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As a... |