Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5091 |
FM-381
FM381 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
FM-381 是一种可逆的JAK3共价抑制剂,靶向 Cys909 位点,对 JAK3 的IC50值为127 pM,选择性分别比 JAK1、JAK2 和 TYK2 高 410、2700 和 3600 倍。 | |||
T22333 |
FM-479
|
Others | Others |
FM-479, an FM-381 structural analog, exhibits no inhibitory potency against JAK3 or other kinases when used at the FM-381 effective dosing range (100-300 nM). FM-479 is used as a negative control for FM-381. | |||
T31832 |
FM-476
|
||
FM-476 is a negative control for FM-381. |