Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62607 |
FLT3-IN-15
|
||
FLT3-IN-15 是一种口服具有活力的、有效的 FLT3 抑制剂,能够作用于 FLT3 (IC50: 0.87 nM) 和 FLT3/D835Y (IC50: 0.32 nM)。FLT3-IN-15 能够用于急性髓系白血病的研究。 | |||
T82392 |
FLT3-IN-23
|
||
FLT3-IN-23作为JFMS样脂氨酸激酶3(FLT3)的抑制剂,表现出7.42 nM的IC50值。该化合物针对带有多种FLT3-TKD与FLT3-ITD-TKD突变的BaF3细胞显示出显著的抗增殖效果。 | |||
T36681 |
Sorafenib N-oxide
|
||
Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibi... | |||
T68497 |
FI-700
|
||
FI-700 is a novel and potent FLT3 inhibitor with promising antileukemia activity. FI-700 showed a potent IC(50) value against FLT3 kinase at 20 nmol/L in an in vitro kinase assay. FI-700 showed selective growth inhibition against mutant FLT3-expressing leukemia cell lines and primary acute myeloid leukemia cells, whereas it did not affect the FLT3 ligand (FL)-driven growth of Wt-FLT3-expressing cells. Oral administration of FI-700 induced the regression of tumors in a s.c. tumor xenograft model ... |