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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7738 |
H3B-6527
|
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
H3B-6527 是一种在 FGF19 驱动的肝细胞癌中有效且选择性的 FGFR4 抑制剂,具有抗肿瘤活性。 | |||
T63704 |
FGFR4-IN-11
|
||
FGFR4-IN-11 是选择性的、有效的、共价结合的 FGFR4 抑制剂 (IC50: 2.1 nM)。FGFR4-IN-11 能够明显抑制 FGF19/FGFR4 信号通路,表现出抗癌效果。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02907 |
FGF-19 Protein, Human, Recombinant
fibroblast growth factor 19,FGF19 |
Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca... | |||
TMPJ-00715 |
FGF-19 Protein, Human, Recombinant (His)
FGF-19,Fibroblast growth factor 19 |
Human | E. coli |
Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile ... |